endocrine deficiencies

Aging Men and Their Hormones
Writing in the medical journal Minerva Ginecologica, researchers say that "The ability to maintain active and independent living for as long as possible is a crucial factor for (aging healthfully)" and that "Interventions such as hormone replacement therapy may alleviate the debilitating conditions of secondary partial endocrine deficiencies by preventing the preventable and delaying the inevitable."

Lunenfeld B. Endocrinology of the aging male. Minerva Ginecol. 2006 Apr;58(2):153-70.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16582870

From the study abstract:
"Despite enormous medical progress during the past few decades, the last years of life are still accompanied by increasing ill health and disability.

The ability to maintain active and independent living for as long as possible is a crucial factor for ageing healthily and with dignity. The most important and drastic gender differences in aging are related to the reproductive organs. In distinction to the course of reproductive ageing in women, with the rapid decline in sex hormones expressed by the cessation of menses, men experience a slow and continuous decline. This decline in endocrine function involves: a decrease of testosterone, dehydroepiandrosterone (DHEA), oestrogens, thyroid stimulating hormone (TSH), growth hormone (GH), IGF1, and melatonin.

The decrease of sex hormones is concomitant with a temporary increase of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition sex hormone binding globulins (SHBG) increase with age resulting in further lowering the concentrations of free biologically active androgens.

These hormonal changes are directly or indirectly associated with changes in body constitution, fat distribution (visceral obesity), muscle weakness, osteopenia, osteoporosis, urinary incontinence, loss of cognitive functioning, reduction in well being, depression, as well as sexual dysfunction.

The laboratory and clinical findings of partial endocrine deficiencies in the aging male will be described and discussed in detail. With the prolongation of life expectancy both women and men today live 1/3 of their life with endocrine deficiencies. Interventions such as hormone replacement therapy may alleviate the debilitating conditions of secondary partial endocrine deficiencies by preventing the preventable and delaying the inevitable."

Article Notes:
Luteinizing hormone is produced in the pituary gland and helps regulate the production of testosterone.
Follicle-stimulating hormone is produced in the pituary gland and helps regulate the production of sperm.

More to read
Hormone Supplementation	Estrogen	Progesterone	Thyroid Main Page
Testosterone - Men	Testosterone - Women	DHEA MAIN PAGE	Insulin
Pregnenolone Main Page		Melatonin Home Page	Diet and Lifestyle

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Marc Darrow, M.D.,J.D.,Q.M.E.

Marc Darrow, M.D., J.D., is an Assistant Clinical Professor at UCLA School of Medicine. He is a world recognized specialist in many chronic disorders. He has been featured in national publications, and television and radio shows, for his innovative approach to medicine. As the medical director of Joint Rehab Center, Inc. in West Los Angeles, Dr. Darrow has helped create an age management program for those individuals interested in maintaining a youthful, healthy vigor for adults through “middle age” and well into the senior years.

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Neither Dr. Darrow, nor any associate of JOINT REHAB AND SPORTS MEDICAL CENTER, INC offer medical advice from this website. This information is offered for educational purposes only. Do not act or rely upon our information without seeking independent professional medical advice. The information on this website does not create a physician-patient relationship between you and Dr. Darrow or any associate of JOINT REHAB AND SPORTS MEDICAL CENTER, INC. Neither Dr. Darrow, nor any associate of JOINT REHAB AND SPORTS MEDICAL CENTER, INC guarantees the accuracy, completeness, usefulness, or adequacy of any resources, information, apparatus, product, or process available at or from this website. MEDICAL MODALITIES MENTIONED ARE MEDICAL TECHNIQUES THAT MAY NOT BE CONSIDERED MAINSTREAM. AS WITH ANY MEDICAL PROCEDURE, RESULTS WILL VARY AMONG INDIVIDUALS, AND THERE COULD BE SUBSTANTIAL RISKS INVOLVED. THESE CONCERNS SHOULD BE DISCUSSED WITH YOUR HEALTH CARE PROVIDER PRIOR TO ANY TREATMENT SO THAT YOU HAVE PROPER INFORMED CONSENT AND UNDERSTAND THAT THERE ARE NO GUARANTEES TO HEALING.

Certain studies including the Woman's Health Initiative suggest that hormone supplementation may increase the risk of certain cancers, heart disease, stroke and other ailments. These risks should be discussed with your health care professional while deciding on, implementing, or continuing Hormone Replacement Therapy (HRT)

The option to use Human Identical Hormones or Bio-identical hormones should also be discussed with your medical care provider as there is not sufficient medical evidence at this time to suggest that they are safer than synthetic hormones and may pose equal risk.

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