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Testosterone in Post Menopausal Women

April 12, 2011 by  
Filed under Testosterone - Women

An article in the medical journal Current Opinion in Obstetrics & Gynecology says that testosterone therapy is a promising option for treating women with HSDD (very low libido or desire)

Somboonporn W.Androgen and menopause.Curr Opin Obstet Gynecol. 2006 Aug;18(4):427-32.

From the article abstract:

PURPOSE OF REVIEW: Androgen therapy is being increasingly used in the management of postmenopausal women. The most common indication is to improve sexual function. The aim of this review is to evaluate current knowledge pertaining to testosterone and sexual function in postmenopausal women.

RECENT FINDINGS: The change of testosterone levels during the menopause transition remains controversial. A correlation of endogenous testosterone levels and sexual function is still inconclusive. A Cochrane Review and recent randomized control trials have, however, consistently demonstrated that short-term testosterone therapy in combination with traditional hormone therapy regimens improves sexual function in postmenopausal women, particularly surgically menopausal women with hypoactive sexual desire disorder.

An adverse effect on the lipid profile has been identified which appears to be mostly associated with oral methyltestosterone. Data for other effects of testosterone and long-terms risks are lacking. Testosterone may act in a variety of ways in different tissues. This is, however, an area that requires further investigation.

SUMMARY: Testosterone therapy is a promising option for treating women with hypoactive sexual desire disorder after surgical menopause. Two remaining questions need to be answer: who is most likely to benefit from testosterone therapy and what are the long-term health risks?

Testosterone For Men

April 12, 2011 by  
Filed under Testosterone - Men

TESTOSTERONE FOR MEN
The medicinal value of testicles have been documented in the Bible, the writings of the ancient Egyptians and from India. Indeed, nearly every ancient culture believed that the testicles held some form of masculine power.

The use of testosterone as a means of restoring vitality can be traced in the modern era to the work of famed medical researcher Charles Edouard Brown-Séquard (1817-1894). Brown-Séquard had been hailed as a medial pioneer for his ability to treat difficult and previously untreatable disorders of the nervous system. At the age of 72, when he noticed his declining vitality, he injected himself with the extracts of crushed testicles from dogs and guinea pigs and increased his physical strength and intellectual abilities and announced his results to his colleagues.

Brown-Séquard’s work sparked an influx of research and medical use of testicles, however, technology could not, at that time, substantiate his claims.

In 1935 Dutch researchers were able to isolate and create a synthetic form of testosterone. Doctors prescribed it in males with hypogonadism—where levels of testosterone are so low it prevents normal sexual development. Older men suffering from impotence were also treated. A few years later, testosterone supplementation for these disorders became “mainstream.”

What are the potential signs of Testosterone deficiency in men?

1. Diminished Libido
2. Erectile Dysfunction
3. Fatigue
4. Muscle Weakness
5. Bone Density Loss, with increased fracture risk
6. Decrease in Endurance, Stamina
7. Loss of Body Hair
8. Depression
9. Mood Disorders
10. Obesity or increase in fat mass
11. Hypertension
Testosterone Supplementation
Testosterone supplementation has received a fair share of “bad press.” Mostly due to health problems (sterility, coronary artery disease, liver damage, and brain tumors), caused in young men and women who should not be taking testosterone supplementation, but do so at super-physiological doses, to enhance athletic performance. Indeed, testosterone is part of the “Steroid Crisis” affecting amateur and professional sports.

There is very little evidence to support that testosterone supplementation to restore levels lost to aging can cause health problems. Numerous research supports the opposite. Study participants and researchers noted gained muscle, a slowdown in bone loss, increased sexual desire, and better cognitive skills.

Drops in testosterone levels begin in men after the age of 30 and its effects are described as “male menopause” or andropause when problematic.

The recognition that men can suffer from sex hormone deficiency just as women do, and be treated for this deficiency in the same manner as women prescribed hormonal supplementation have lead to an explosion in the demand for testosterone supplementation.

Testosterone Supplementation Risks
It is important to understand that not all men will benefit from Testosterone supplementation. The goals, realities, and risks of Testosterone supplementation should be discussed, at length, with your physician prior to onset of treatment.

Testosterone Supplementation and Prostate Cancer
Men taking testosterone supplementation should have twice yearly PSA tests and once yearly manual examination of their prostate gland. No evidence suggests that testosterone supplementation causes prostate cancer. In fact, studies show a higher incidence of prostate cancer in men with a lower baseline level of testosterone. Have you ever heard of a teen age male (with the highest testosterone levels) having prostate cancer? Studies do suggest that in the presence of existing prostate cancer, testosterone supplementation may accelerate tumor growth. It also appears that there is an association of high estrogen levels and prostate cancer.

Warnings:
Any hormone supplementation can adversely effect other hormone levels.

Testosterone supplementation must be monitored by a physician through blood testing. Very high levels of testosterone can lead to severe and dangerous health problems.

Men who take too much Testosterone may can shut down production of DHEA and other sex hormones.

The result is the frequently seen side effects of:
1. Testicular shrinkage
2. Impotence
3. The development through increased estrogen production of breasts (gynecomastia).
4. Male Pattern Baldness
5. Infertility

Other complications may include:
1. Fluid retention (swelling)
2. Heart Problems through increasing hardening of the arteries.
3. Increase in body hair
4. Acne
5. Liver problems
6. Kidney disease
7. High Blood Pressure
8. Gallstones

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