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Alzheimer's Disease |
Insulin and Aging
A new study, to be published, says that high insulin levels,
among both diabetics and non-diabetics, may contribute to
Alzheimer's disease.
To quote the authors of the study "Although this model has
obvious relevance for diabetes mellitus,
hyperinsulinemia
and insulin resistance are widespread conditions that affect
many nondiabetic adults with obesity, impaired glucose
tolerance, cardiovascular disease, and hypertension. Our
results provide a cautionary note for the current epidemic
of such conditions, which, in the context of an aging
population, may provoke a dramatic increase in the
prevalence of AD (Alzheimer's)."
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Obesity and vascular risk
factors at midlife and the risk of dementia and Alzheimer
disease.
Kivipelto M, Ngandu T,
Fratiglioni L, Viitanen M, Kareholt I, Winblad B, Helkala EL,
Tuomilehto J, Soininen H, Nissinen A. Arch Neurol. 2005
Oct;62(10):1556-60.
From the abstract: "Obesity
at midlife is associated with an increased risk of dementia and
AD (Alzheimer's Disease) later in life. Clustering of
vascular risk factors increases the risk in an additive manner.
The role of weight reduction for the prevention of dementia
needs to be further investigated."
Read the abstract |
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Brain Estrogen Deficiency and Alzheimer's
Disease
 Writing
in the Proceedings of the National Academy of Sciences (USA),
researchers studied the effects of estrogen deficiency and
Alzheimer's Disease. They wrote: "Much evidence indicates that women have a higher risk
of developing Alzheimer's disease (AD) than do men. The
reason for this gender difference is unclear. We
hypothesize that estrogen deficiency in the brains of
women with AD may be a key risk factor....Our results
indicate that estrogen depletion in the brain may be a
significant risk factor for developing AD
neuropathology."
Yue X,
Lu M, Lancaster T, Cao P, Honda SI, Staufenbiel M, Harada N,
Zhenyu Z, Shen Y, Rena Li R Brain estrogen deficiency accelerates Aβ
plaque formation in an Alzheimer's disease animal model Proc. Natl. Acad. Sci. USA,
10.1073/pnas.0505203102 |
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Melatonin and Alzheimer-like
neurodegeneration
 Writing
in the medical journal Acta Pharmacologica Sinica, researchers
studied the effect of melatonin and cognitive impairment. They
wrote: "Alzheimer disease (AD), an age-related neurodegenerative
disorder with progressive loss of memory and deterioration of
comprehensive cognition, is characterized by extracellular
senile plaques of aggregated beta-amyloid (Abeta), and
intracellular neurofibrillary tangles that contain
hyperphosphorylated tau protein. Recent studies showed that
melatonin, an indoleamine secreted by the pineal gland, may play
an important role in aging and AD as an antioxidant and
neuroprotector. Melatonin decreases during aging and patients
with AD have a more profound reduction in this hormone. Data
from clinical trials indicate that melatonin supplementation
improves sleep, ameliorates sundowning, and slows down the
progression of cognitive impairment in Alzheimer patients."
Wang JZ, Wang ZF. Acta Pharmacol Sin. 2006 Jan;27(1):41-9.
Read the abstract here:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16364209
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Obesity and Alzheimer’s Disease
Researchers say that obesity can
lead to higher risk of Alzheimer's disease.
From the press release issued by
Thomas Jefferson University Hospital: "A team led by researchers
at the Farber Institute for Neurosciences at Thomas Jefferson
University in Philadelphia and Edith Cowan University in
Joondalup, Western Australia has shown that being extremely
overweight or obese increases the likelihood of developing
Alzheimer’s. They found a strong correlation between body
mass index and high levels of beta-amyloid, the sticky protein
substance that builds up in the Alzheimer’s brain and is thought
to play a major role in destroying nerve cells and in cognitive
and behavioral problems associated with the disease."
http://www.jeffersonhospital.org
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Exercise Delays Onset of
Dementia and Alzheimer's
Larson EB, Wang L, Bowen
JD,McCormick WC, Teri L, Crane P, Kukull W. Exercise Is
Associated with Reduced Risk for Incident Dementia among Persons
65 Years of Age and Older. Annals of Internal Medicine January
17, 2006 Volume 144 Issue 2 Pages 73-81.
A new study reports a reduced incidence rate of dementia for
people who exercised 3 or more times a week compared with those
who exercised fewer than 3 times per week.
Say the study authors: "We believe these findings may be useful
if they are confirmed because Alzheimer disease is one of the
most feared illnesses of aging and is frequently cited as a
reason for not wanting to "get old": People do not want to lose
their independence and quality of life as a consequence of
aging."
They conclude: "These results suggest that regular exercise is
associated with a delay in onset of dementia and Alzheimer
disease, further supporting its value for elderly persons."
Read the full article here at the Annals of Internal Medicine |
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Obesity and
Alzheimer's
Midlife Obesity Raises
Risk of Alzheimer’s Disease Later
Researchers reporting at the American Academy of Neurology 58th
Annual Meeting in San Diego this week say that midlife obesity
raises the risk for Alzheimer's. Read
more |
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Testosterone, Alzheimer's, Mood and Quality of Life
A study suggets that that testosterone replacement
therapy improved overall quality of life in patients
with Alzheimers Disease. |
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Brain Estrogen Deficiency and Alzheimer's
Disease
Writing
in the Proceedings of the National Academy of Sciences (USA),
researchers studied the effects of estrogen deficiency and
Alzheimer's Disease. They wrote: "Much evidence indicates that women have a higher risk
of developing Alzheimer's disease (AD) than do men. The
reason for this gender difference is unclear. We
hypothesize that estrogen deficiency in the brains of
women with AD may be a key risk factor....Our results
indicate that estrogen depletion in the brain may be a
significant risk factor for developing AD
neuropathology."
Yue X,
Lu M, Lancaster T, Cao P, Honda SI, Staufenbiel M, Harada N,
Zhenyu Z, Shen Y, Rena Li R Brain estrogen deficiency accelerates Aβ
plaque formation in an Alzheimer's disease animal model Proc. Natl. Acad. Sci. USA,
10.1073/pnas.0505203102 |
|
Melatonin and Alzheimer-like
neurodegeneration
Writing
in the medical journal Acta Pharmacologica Sinica, researchers
studied the effect of melatonin and cognitive impairment. They
wrote: "Alzheimer disease (AD), an age-related neurodegenerative
disorder with progressive loss of memory and deterioration of
comprehensive cognition, is characterized by extracellular
senile plaques of aggregated beta-amyloid (Abeta), and
intracellular neurofibrillary tangles that contain
hyperphosphorylated tau protein. Recent studies showed that
melatonin, an indoleamine secreted by the pineal gland, may play
an important role in aging and AD as an antioxidant and
neuroprotector. Melatonin decreases during aging and patients
with AD have a more profound reduction in this hormone. Data
from clinical trials indicate that melatonin supplementation
improves sleep, ameliorates sundowning, and slows down the
progression of cognitive impairment in Alzheimer patients."
Wang JZ, Wang ZF. Acta Pharmacol Sin. 2006 Jan;27(1):41-9.
Read the abstract here:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16364209 |
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Cortisol
Concentrations Predict a
Decline in Memory Function
Researchers writing in the medical journal Neurobiology of Aging
say their "results partially confirm previous findings that high
cortisol is associated with impaired declarative memory function
in non-demented older persons. In addition, our data show that
high salivary cortisol concentrations predict a decline in
memory function over the next 3 years."
Read more |
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Ageless
-
Suzanne Somers
"As my personal sports
doctor, (Dr. Darrow) has never given me a drug for any of my
injuries. He is of the thinking that unless a drug is necessary, it
is better to allow inflammation to do nature's work." (page 130).
Marc Darrow,
M.D.,J.D.,Q.M.E.
Marc Darrow, M.D., J.D.,
is an Assistant
Clinical Professor at UCLA School of Medicine. He is a world recognized
specialist in many chronic disorders. He has been featured in national
publications, and television and radio shows, for his innovative
approach to medicine. Dr. Darrow has helped create an age management program for those
individuals interested in maintaining a youthful, healthy vigor
 for
adults through “middle age” and well into the senior years.
Patient Information
Joint
Rehabilitation and Prolotherapy Information
Marc Darrow, M.D.,J.D.,Q.M.E.
Marc Darrow, M.D., J.D.,
is an Assistant
Clinical Professor at UCLA School of Medicine. He is a world recognized
specialist in many chronic disorders. He has been featured in national
publications, and television and radio
shows, for his innovative
approach to medicine. As the medical director of Joint Rehab
Center, Inc. in West Los Angeles, Dr. Darrow has helped create an age management program for those
individuals interested in maintaining a youthful, healthy vigor for
adults through “middle age” and well into the senior years.
Why am I so driven to work in
the age management field? Basically
it was for my own personal, mental, and
spiritual well being. Read what
Dr. Darrow has to say about how he got interested in age management!
DISCLAIMER:
Neither
Dr. Darrow, nor any associate of JOINT
REHAB AND SPORTS MEDICAL CENTER, INC offer medical advice from this website. This
information is offered for educational purposes only. Do not
act or rely upon our information without seeking independent
professional medical advice. The information on this website
does not create a physician-patient relationship between you
and Dr. Darrow or any associate of JOINT REHAB AND SPORTS
MEDICAL CENTER, INC.
Neither Dr. Darrow, nor any associate of JOINT REHAB AND
SPORTS MEDICAL CENTER, INC
guarantees the accuracy, completeness, usefulness, or
adequacy of any resources, information, apparatus, product,
or process available at or from this website. MEDICAL
MODALITIES MENTIONED ARE MEDICAL TECHNIQUES THAT MAY NOT BE
CONSIDERED MAINSTREAM. AS WITH ANY MEDICAL PROCEDURE,
RESULTS WILL VARY AMONG
INDIVIDUALS, AND THERE COULD BE SUBSTANTIAL RISKS INVOLVED.
THESE CONCERNS SHOULD BE DISCUSSED WITH YOUR HEALTH CARE
PROVIDER PRIOR TO ANY TREATMENT SO THAT YOU HAVE PROPER
INFORMED CONSENT AND UNDERSTAND THAT THERE ARE NO GUARANTEES
TO HEALING.
Certain studies including the Woman's Health
Initiative suggest that hormone supplementation may
increase the risk of certain cancers, heart disease,
stroke and other ailments. These risks should be
discussed with your health care professional while
deciding on, implementing, or continuing Hormone
Replacement Therapy (HRT)
The option to use Human Identical Hormones or Bio-identical hormones should also be
discussed with your medical care provider as there is
not sufficient medical evidence at this time to suggest
that they are safer than synthetic hormones and may pose
equal risk.
If you have or suspect that
you have a medical problem, condition or issue, promptly
contact your health care provider. The statements on this
website have not been evaluated by the Food and Drug
Administration. The photos in this Web site feature models
for illustrative purposes. |
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