Insulin Resistance and Metabolic Syndrome
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
Insulin Resistance Tied To Age-Related Muscle Loss
Writing in the medical journal Diabetes and Metabolism, researchers say: “…insulin resistance could be involved in age-related muscle protein loss, progressively leading to sarcopenia. Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.”
Insulin Resistence: What Do Some Researchers Say?
When we eat, our bodies release insulin into our blood stream so that we can process glucose (sugars) from our foods to make energy, especially in our muscles. Glucose belongs in our cells and not in our blood. When it remains in our blood we produce more insulin. Increased insulin, according to many researchers, is the number one factor for accelerated aging.
What is the Effect of Insulin Resistance and Loss of Lean Muscle (Sarcopenia) As We Age?
Researchers writing in the Journal of The Federation of American Societies for Experimental Biology say: “A reduced response of older skeletal muscle to anabolic stimuli (exercise & diet) may contribute to the development of sarcopenia. Skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia.”
Metabolic Syndrome and Stroke
Researchers writing in the Archives of Internal Medicine say that preventing and controlling Metabolic Syndrome is likely to reduce risk of stroke.
Stress at Work and Metabolic Syndrome
Metabolic Syndrome is a combination of symptoms including high blood pressure, abdominal obesity, insulin resistance and others related to coronary heart disease.
Metabolic Syndrome and Stroke
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
Najarian RM, Sullivan LM, Kannel WB, Wilson PW, D’Agostino RB, Wolf PA.Metabolic Syndrome Compared With Type 2 Diabetes Mellitus as a Risk Factor for Stroke: The Framingham Offspring Study. Arch Intern Med. 2006 Jan 9;166(1):106-111.
Researchers writing in the Archives of Internal Medicine say that preventing and controlling Metabolic Syndrome is likely to reduce risk of stroke.
From the abstract: “Metabolic syndrome has been recognized as a prediabetic constellation of symptoms and an independent risk factor for cardiovascular disease.”
They concluded: “Metabolic syndrome is more prevalent than diabetes and a significant independent risk factor for stroke in people without diabetes. Prevention and control of (Metabolic Syndrome) and its components are likely to reduce stroke incidence.”
What is the Effect of Insulin Resistance and Loss of Lean Muscle (Sarcopenia) As We Age?
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
Sarcopenia – Loss of Lean Muscle
Leucine – An amino acid found in protein rich foods
Researchers writing in the Journal of The Federation of American Societies for Experimental Biology say: “A reduced response of older skeletal muscle to anabolic stimuli (exercise & diet) may contribute to the development of sarcopenia.
Skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia.”
Writing in Diabetes and Metabolism, French Researchers say:
“Structural and functional modifications occur in skeletal muscle during aging. These defects lead to impairment in muscle strength, contractile capacity and performance.
Among factors implicated in this age-related loss of muscle mass, a dysregulation of protein synthesis and breakdown has frequently been reported.
Insulin plays a major role in regulating muscle protein metabolism, since its action contributes to increase net gain of muscle protein in animal and humans.
Insulin resistance develops with aging, classically involving changes in glucose tolerance. However, the effect of insulin on protein metabolism is less well documented, and insulin resistance could be involved in age-related muscle protein loss, progressively leading to sarcopenia. Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.”
Insulin Resistance Tied To Age-Related Muscle Loss
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
Writing in the medical journal Diabetes and Metabolism, researchers say: “…insulin resistance could be involved in age-related muscle protein loss, progressively leading to sarcopenia. Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.”
Guillet C, Boirie Y. Insulin resistance: a contributing factor to age-related muscle mass loss? Diabetes Metab. 2005 Dec;31 Spec No 2:20-6.
Related Articles
Insulin Resistance, Weight Gain Lead to Early Aging
“Tulane University researchers are the first to demonstrate a biological link between insulin resistance, weight gain and signs of early aging in the blood…”
Insulin Research Articles
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
Insulin and Aging
A new study, to be published, says that high insulin levels, among both diabetics and non-diabetics, may contribute to Alzheimer’s disease.
To quote the authors of the study “Although this model has obvious relevance for diabetes mellitus, hyperinsulinemia and insulin resistance are widespread conditions that affect many nondiabetic adults with obesity, impaired glucose tolerance, cardiovascular disease, and hypertension. Our results provide a cautionary note for the current epidemic of such conditions, which, in the context of an aging population, may provoke a dramatic increase in the prevalence of AD (Alzheimer’s).”
You can read the entire article from the Journal of Neurology
Insulin Resistance Tied To Age-Related Muscle Loss
Writing in the medical journal Diabetes and Metabolism, researchers say: “…insulin resistance could be involved in age-related muscle protein loss, progressively leading to sarcopenia. Therefore in a more general concept, insulin resistance found in many clinical settings, could be considered as a contributor to muscle wasting.”
Guillet C, Boirie Y. Insulin resistance: a contributing factor to age-related muscle mass loss? Diabetes Metab. 2005 Dec;31 Spec No 2:20-6.
Insulin Resistance, Weight Gain Lead to Early Aging
“Tulane University researchers are the first to demonstrate a biological link between insulin resistance, weight gain and signs of early aging in the blood…”
UCSD Study Sheds New Light on Insulin’s Role in Blocking Fat Breakdown in Patients with Type II Diabetes
“Chronically high levels of insulin, as is found in many people with obesity and Type II diabetes, may block specific hormones that trigger energy release into the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine. Their findings, which may point to new approaches to developing improved treatment options for the disease…”
Insulin
April 12, 2011 by Dr. Marc Darrow, M.D.
Filed under Insulin
By Controlling Insulin, You May Be Controlling Aging
When we eat, our bodies release insulin into our blood stream so that we can process glucose (sugars) from our foods to make energy, especially in our muscles.
Glucose belongs in our cells and not in our blood. When it remains in our blood we produce more insulin. Increased insulin, according to many researchers, is the number one factor for accelerated aging.
Glucose
Our cells need glucose for many things including energy, metabolism, and for mood and cognitive function. The short term benefit of eating a candy bar, besides its good taste, has long been know by athletes and students, sugar gives you energy and makes you think straight, that is, in the short-term.
The reason we cannot eat large amounts of glucose is obvious. We would get fat, develop insulin resistance, and then diabetes.
When we eat too much glucose, as sugar or in the form of high-glycemic carbohydrates, more insulin is needed to be released to usher the glucose into the cells.
The insulin receptors in our cells down-regulate and we become insulin resistant. We are then on a the path to Metabolic Syndrome and probably Type II Diabetes.
Glycation
Glycation is one of the most significant biologic markers of aging.
High blood sugar produces Advanced Glycation End-Products (AGEs). Very dangerous chemicals produced by sugar-protein-fat reactions that attack collagen and DNA and also produce Interleukin 6-the root cause of inflammation. Glycation is a major cause of inflammation that triggers degenerative disease.
By minimizing glycation you can add years of vitality, productivity, and great health to your healthspan.
