Thyroid Articles

Thyroid in Women Over 50
You are gaining weight and losing your hair, because of these “characteristics of aging,” you realize that you are getting older and now you have made yourself depressed. Is this aging or is it low-thyroid?

Estimates say that by age 50, 10% of women will be hypothyroid (not producing enough thyroid hormone) and by age 60 that number can nearly double.

You won’t need a scientific study to know that once over the age of 50, maintaining proper body weight becomes more difficult. When a person become hypothyroid staying trim and fit becomes nearly impossible.

The Evil Cycle of Weight Gain and Hypothyroidism
The Thyroid is a master gland participating and controlling the function of all the major body organs. When thyroid hormone is not produced in sufficient quantities to regulate our energy levels (hypothyroidism), our metabolism slows down to a crawl. This has the following weight gain effect.

1. Even on reduced calorie diets, your metabolism will not burn enough calories and you will retain weight.

2. A slow down in metabolism means a drop in energy and the inability to exercise or lead a sufficiently active life to stay trim.

3. Another consequence of hypothyroidism is constipation, accumulated fecal matter accounts for significant pounds.

4. Let’s add water retention for that bloated feeling.

Diagnosis of Hypothyroidism
Hypothyroidism is not easily diagnosed by physicians because the symptoms are that which are routinely attributed to old age, that is the loss of energy, weight gain, etc. A “Thyroid Panel,” measuring TSH, T3, and T4 levels should be part of a basic blood chemistry panel in everyone over 30 so this “old age issue,” may be treated.

Beyond the Blood Test
Sometimes a suspected Thyroid problem can show “normal blood tests” it is important for the women and the doctor who suspect that thyroid is a problem to look for the following besides those symptoms, weight gain, depression, thinning or losing hair mentioned above.

Especially significant are
* memory and mood disorders
* cold sensitivity
* and menstrual problems

Even after you are put on thyroid supplementation, it is important to monitor these symptoms and your general overall health so that you can guide your physician and together your thyroid the type and amount of thyroid supplementation can be altered to help you be the best you can.

Thyroid Main Page

Melatonin Research

Blood Pressure
Scheer FA, Van Montfrans GA, van Someren EJ, et al. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 2004;43:192-7.

Study: Researchers sought to examine whether hypertension could be lowered by better sleep.

The researchers stated: “In patients with essential hypertension, repeated bedtime melatonin intake significantly reduced nocturnal blood pressure. Future studies in larger patient group should be performed to define the characteristics of the patients who would benefit most from melatonin intake. The present study suggests that support of circadian pacemaker function may provide a new strategy in the treatment of essential hypertension.”

Melatonin’s Beneficial Effects on Night-Time Blood Pressure and Women Aged 47 to 63
Researchers writing in the American Journal of Hypertension examined the question: “The nocturnal decline of blood pressure (BP) is almost coincident with the elevation of melatonin, which may exert vasodilatating and hypotensive effects. In this study we investigated whether prolonged nocturnal administration of melatonin could influence the daily rhythm of BP in women.”

How was the study conducted?
“In a randomized double-blind study, 18 women, 47 to 63 years of age (nine with normal blood pressure and nine being treated treated for essential hypertension) received a 3-week course of a slow-release melatonin pill (3 mg) or placebo 1 hour before going to bed. They were then crossed over to the other treatment for another 3 weeks.”

What did they conclude?
“In comparison with placebo, melatonin administration did not influence (daytime) BP but did significantly decrease nocturnal systolic, diastolic, and mean BP without modifying heart rate. The effect was inversely related to the day–night difference in BP…These data indicate that prolonged administration of melatonin may improve the day–night rhythm of BP, particularly in women with a blunted nocturnal decline.”

Cagnaccia A, Cannolettaa M, Renzia A, Baldassaria F, Aranginob S, Volpea A. Prolonged Melatonin Administration Decreases Nocturnal Blood Pressure in Women. American Journal of Hypertension. Volume 18, Issue 12, Pages 1614-1618

Immune Stimulation
Poon AM, Liu ZM, Pang CS, et al. Evidence for a direct action of melatonin on the immune system. Biol Signals. 1994 Mar-Apr;3(2):107-17.

From the abstract: “Pineal melatonin modulates the mammalian immune system. In vivo studies showed that melatonin enhanced the natural and acquired immunity while in vitro studies demonstrated its inhibitory influence.”

Melatonin, Immune Function and Aging
Researchers writing in the medical Journal Immunity & Aging say: (From the abstract) “Aging is associated with a decline in immune function (immunosenescence), a situation (sp) known to correlate with increased incidence of cancer, infections and degenerative diseases….Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state.”

Venkatramanujam Srinivasan, Georges J.M. Maestroni, Daniel P. Cardinali, Ana I. Esquifino, S. R. Pandi-Perumal and Sandra C. Miller. Melatonin, Immune Function and Aging. Immunity & Ageing 2005, 2:17

Read the abstract

Melatonin Randomized Trial for Insomnia in the Elderly
Nalaka S. Gooneratne, MD,MSc, Principal Investigator, University of Pennsylvania
Study start: October 2004; Expected completion: July 2007

From the study details “Melatonin is a hormone secreted predominantly during the sleep period, suspected to have a strong link to the circadian sleep-wake cycle. Melatonin is also available in a pill form and, when administered during the day, tends to have a sedative effect. Clinical trials that have examined the nocturnal effects of melatonin have focused on patients of any age who have insomnia, regardless of their endogenous melatonin levels. Data indicate, however, that individuals with low endogenous melatonin levels may be more responsive to exogenous melatonin. Generally, melatonin levels decrease with age; therefore, older individuals with insomnia represent an ideal population in which to study the effects of exogenous melatonin on sleep. This study will provide older adults with insomnia melatonin tablets to determine whether the tablets will increase their sleep.”

Read more about this current research

Melatonin and Alzheimer-like Neurodegeneration
Writing in the medical journal Acta Pharmacologica Sinica, researchers studied the effect of melatonin and cognitive impairment. They wrote: “Alzheimer disease (AD), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized by extracellular senile plaques of aggregated beta-amyloid (Abeta), and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein. Recent studies showed that melatonin, an indoleamine secreted by the pineal gland, may play an important role in aging and AD as an antioxidant and neuroprotector. Melatonin decreases during aging and patients with AD have a more profound reduction in this hormone. Data from clinical trials indicate that melatonin supplementation improves sleep, ameliorates sundowning, and slows down the progression of cognitive impairment in Alzheimer patients.” Wang JZ, Wang ZF. Acta Pharmacol Sin. 2006 Jan;27(1):41-9.

Read the abstract here

Does Melatonin Protect Vision As We Age?
Researchers writing in the Journal of Pineal Research say that Melatonin maybe beneficial in preserving visual functions.

Excerpts from the study abstract:
“Current evidence suggests that melatonin may act as a protective agent in ocular conditions such as photo-keratitis, cataract, glaucoma, retinopathy of prematurity and ischemia/reperfusion injury.

These diseases are sight-threatening and they currently remain, for the most part, untreatable. The pathogenesis of these conditions is not entirely clear but oxidative stress has been proposed as one of the causative factors.

Oxidative damage in the eye leads to apoptotic degeneration of retinal neurons and fluid accumulation. Retinal degeneration decreases visual sensitivity and even a small change in the fluid content of the cornea and crystalline lens is sufficient to disrupt ocular transparency. In the eye, melatonin is produced in the retina and in the ciliary body. Continuous regeneration of melatonin in the eye offers a frontier antioxidative defense for both the anterior and posterior eye.

However, melatonin production is minimal in newborns and its production gradually wanes in aging individuals as indicated by the large drop in circulating blood concentrations of (Melatonin).

These individuals are possibly at risk of contracting degenerative eye diseases that are free radical-based. Supplementation with melatonin, a potent antioxidant, in especially the aged population should be considered as a prophylaxis to preserve visual functions.”

Siu AW, Maldonado M, Sanchez-Hidalgo M, Tan DX, Reiter RJ. Protective effects of melatonin in experimental free radical-related ocular diseases. J Pineal Res. 2006 Mar;40(2):101-9.

Desire, Arousal, and Satisfaction in Aging Women

Researchers writing ion the medical journal Minerva Ginecologica examined issues related to aging and desire and arousal.

Nappi RE, Albani F, Valentino V, Polatti F, Chiovato L, Genazzani AR. Aging and sexuality in women. Minerva Ginecol. 2007 Jun;59(3):287-298.

A large number of biological, psycho-relational and socio-cultural factors are related to women’s sexual health and they may negatively affect the entire sexual response cycle inducing significant changes in sexual desire, arousal, orgasm and satisfaction during the entire reproductive life span.

In spite of the high prevalence of sexual problems with increasing age, sexual retirement is not an inevitable consequence of the passage of time and a high proportion of men and women remains sexually active well into later life, a result of changing attitudes toward sexuality and the availability of effective treatments for sexual dysfunction.

Population-based studies reported an age-related decline of sexual functioning and an additional adverse effect of menopausal status. Ageing per se interferes with the level of sexual performance, but sexual behaviour of midlife and older women is highly dependent on several factors such as general physical and mental well-being, quality of relationship and life situation.

Sex hormones, mainly low levels of estradiol, are relevant for the lack of sexual awareness and vaginal receptivity in naturally menopausal women.

Even diminished levels of androgens, as it more frequently occurs in surgically menopausal women, has a negative impact on desire and sexual responsiveness.

Several hormonal treatments have been used locally or systemically to alleviate sexual symptoms, especially by using estrogen plus androgen preparations and tibolone, with noticeable results on drive, enjoyment, lubrication, ability to reach orgasm and initiation of sex. However, sexual counseling and individualized management is mandatory to obtain meaningful and long-lasting results in clinical practice.

Estrogen

There is a great deal of fear and confusion when it comes to menopause and hormone supplementation. First, the term Hormone Replacement Therapy or HRT can conjure up the image of a cancer, stroke, and heart disease causing cocktail of synthetic hormones.

Next there is the “alternative,” Natural Hormone Replacement Therapy (NHRT). There is no Natural Hormone Replacement Therapy. Hormones for use in humans need to be synthesized from something. While many use the term, it is the sometimes favorite of internet sites selling “hormones,” and thus an easy target for critics who still favor the use of horse hormones and point to the “NHRT” websites as those making unsupported claims and being medically dangerous.

Sometimes, but incorrectly added to the latter group are the aptly and descriptively named “Bio-Identical Hormones.” Bio-identical Hormone Replacement Therapy (BHRT) is not “natural” hormones and should never be referred to as that. Their sources are natural, being derived from plant sources, but, they must be chemically altered to exactly match the hormones produced in the body.

This is where the “natural” confusion comes in. Bio-identical Hormones are engineered to exactly match the natural hormones present in the body, but they themselves are not “natural” but indeed, bio-identical.

I would like to point out here that NOT every woman coming in with peri-menospausal, menopausal or post-menopausal complaints is put on hormone therapy at our clinic and there are no studies that clearly show that bio-identical hormones are any safer than synthetic hormones.

Sometimes the desired results a women wants can be achieved by quitting smoking or drinking, altering a diet to avoid foods that could aggravate symptoms, such as coffee, sugars, and foods loaded with chemicals, getting more exercise, reducing stress, reducing exposure to caustic elements and more.

There are options to Hormone Replacement Therapy and these can and should be discussed with a physician knowledgeable in understanding all the options available to the peri-menospausal and menopausal woman. Just because Grandma went through menopause naturally, doesn’t mean she was the better for it!

Hormone replacement, peri-menopause and menopause
For over four decades doctors freely prescribed synthetic estrogen replacement to women in the throes of menopause to alleviate the myriad of symptoms associated with the “Change of Life.” It was an easy thing to do. A women would come in with “hot flashes,” “mood swings,” and “fatigue,” among other complaints and the doctor would simply give them estrogen. Why not? The women who took estrogen seemed to be more youthful, enjoy life more, and “had control of their bodies.”

The problem became supplying the demand for estrogen. To which “Estrogen Farms,” were set up to capture the urine of pregnant mares (where the name Premarin comes from (Pre=Pregnant, Mar=Mare, In=Urine) to glean the estrogen from it.

Synthetic horse-urine estrogen replacement was now the vogue and over 10,000,000 women were “in style.” Physicians felt comfortable putting women on this estrogen, since many studies proclaimed the vast benefits of estrogen replacement therapy. In fact, once on horse-estrogen, many women refused and still refuse to give it up!

Happy with horse estrogen

After menopause, estrogen levels in a woman’s body declines.

Estrogen Replacement Therapy (ERT) alleviated the familiar symptoms of menopause for many women.
With this decline often comes the familiar symptoms of:
1. Vaginal dryness, painful intercourse
2. Vaginal mucosal atrophy
3. Hot flashes
4. Night sweats
5. Fatigue
6. Mood swings and memory problems
7. Fluid retention
8. Sleep problems
9. Decreased libido
10. Involuntary loss of urine (stress incontinence)
11. More frequent urinary tract infections

It seemed like an idyllic world. Women wanted estrogen, the doctors were eager to comply, and the pharmaceutical industry was happy to produce.

Then on July 12, 2002, the world of synthetic estrogen replacement abruptly collapsed and panic filled women across the world. The Journal of the American Medical Association (JAMA) reported that Hormone Replacement Therapy was too dangerous to research!

Estrogen Segments 1 2 3

Ask A Question?

Hormone Replacement

Hormone Supplementation

What are hormones?
What is hormone supplementation?
How does it enhance vitality even as we age?

Hormones are chemicals within our bodies responsible for many things including the regulation of our metabolism, immune function, blood pressure, sugar levels, body temperature as well as a host of other things including regrowth and repair of damaged tissue. They are produced by our glands, namely the Thyroid (Thyroid), Adrenals (DHEA, Pregnenolone), Pituitary (Human Growth Hormone (HGH)), Ovaries (Estrogen, Progesterone, Testosterone) or Testes (Testosterone), and Pineal (Melatonin). After about the age of 30, our body’s hormone levels start to decline. Many cite this decline with the “normal” aspect of aging and its familiar characteristics of fatigue and loss of energy, problems of memory and mood, lack of ambition, loss of libido, weight gain and muscle loss and much more that add up to a sense of poor health. This hormonal decline continues as we age, and usually becomes problematic in our 40’s and 50’s, although, it can create issues at an even younger age. An example are the statin drugs that can cause a dramatic decrease in testosterone even at a young age. With testosterone decline, we find incidence of erectile dysfunction.

Giving “pause” to thought We have all heard of and embraced the term menopause to describe a decline in the female sex hormones, but there are other “pauses” that are becoming more recognizable as house-hold names. Doctors have coined the terms “andro-pause” to describe the decline of male sex hormones in men, “somatopause” to describe the decrease in human growth hormone, “adrenalpause” to describe a decline in DHEA, and “pinealpause” to describe a decline in melatonin.

In the opinion of many doctors, maintaining optimal hormonal balance is our best opportunity to enhance vitality into “old age” and overcome these “pauses” in life. Some doctors however believe that aging is inevitable and that nothing can be done about it except to accept it gracefully. This is a stigma of modern medicine. On one hand, medicine is proud, and rightfully so, of enormous jumps in life expectancy ages, but on the other hand, they are skeptical about enhancements in quality of life. Therefore some doctors may be reluctant to treat hormonally deficient patients because they see this as a normal result of aging, and something they can’t do anything about.

In other words a 70 year-old man presents himself to the doctor’s office with complaints of loss of sex drive, fatigue, and inability to lose weight. It is likely that his doctor will say, “You are 70 years old, and this is normal for your age!”, rather than take blood tests of hormone levels. If the patient was insistent about getting his hormones checked the doctor may see “normal” results, that are the normal ranges for a man 70 years old and tell the patient that he is normal. But the patient isn’t “normal,” that is why he went to his doctor! He doesn’t want the hormones of a 70 year-old man, he wants the hormones necessary to have sex drive, muscle tone, strength, ambition, joy, and his vitality back. He also wants a good chance to be free of heart disease, diabetes mellitis, and other diseases of aging. Why not check his c-reactive protein, fasting insulin, and homocysteine levels, along with many other markers of hidden disease?

Hormone Supplementation Parts 1 2 3

Hypoandrogen-Metabolic Syndrome in Men

Gould DC, Kirby RS, Amoroso P. Hypoandrogen-metabolic syndrome: a potentially common and underdiagnosed condition in men. Int J Clin Pract. 2007 Feb;61(2):341-4.

Researchers writing in the International Journal of Clinical Practice say Men with (Hypoandrogen-metabolic syndrome) and symptoms of androgen deficiency may be managed by, in the absence of contraindications, testosterone replacement therapy along with weight reduction and other measures to normalize glucose, lipid and blood pressure control.

The researchers noted that symptoms of androgen deficiency (hypoandrogenaemia (hypogonadism, hypotestosteronaemia) may be a common accompanying factor in men with the metabolic syndrome and when androgen deficiency and metabolic syndrome are present together “they may be considered as a specific entity, the hypoandrogen-metabolic (HAM) syndrome.”

The researchers concluded: “The prevalence of both hypoandrogenaemia and the metabolic syndrome increases with age and the clinician will frequently attend to men in their middle to advanced years with obesity, low androgen levels and metabolic syndrome.

These conditions place men at an increased risk of cardiovascular and coronary heart disease and type 2 diabetes and can be simply investigated with weight, waist and blood pressure measurement and blood sample analyses.

Men with HAM and symptoms of androgen deficiency may be managed by, in the absence of contraindications, testosterone replacement therapy along with weight reduction and other measures to normalise glucose, lipid and blood pressure control.”

Testosterone and the Aging Male

A published report in the medical journal Aging Male says “The wide-ranging benefits of testosterone therapy in young and old men are clear and it appears that the route of administration (intramuscular, oral, or transdermal) does not alter this fact, but future work could illustrate even more profound effects of testosterone (e.g., in reducing cardiovascular risk) that could result in its recommended use in a wider range of patients.”

Abstratct:

Kohn FM. Testosterone and body functions. Aging Male. 2006 Dec;9(4):183-8

Testosterone supplementation can help reduce many of the symptoms associated with androgen deficiency in the aging male by its effects on various parts of the body.

Bone mineral density can decrease in the hypogonadal man and this may contribute to the increased fracture rate in the elderly. Testosterone therapy can improve bone mineral density and bone architecture by increasing bone formation and decreasing bone resorption – the possible benefits on fracture rate are unknown.

Testosterone also improves body composition by reducing body fat mass and increasing lean body mass, and by increasing epidermal thickness, but its effects on muscle strength are still debated.

In patients with diabetes and androgen deficiency, testosterone supplementation appears to reduce blood glucose and this could have important implications for cardiovascular risk reduction in patients with diabetes or the metabolic syndrome.

The wide-ranging benefits of testosterone therapy in young and old men are clear and it appears that the route of administration (intramuscular, oral, or transdermal) does not alter this fact, but future work could illustrate even more profound effects of testosterone (e.g., in reducing cardiovascular risk) that could result in its recommended use in a wider range of patients.

Hormone Supplementation

HORMONE  SUPPLEMENTATION
An indisputable fact in medicine is that we do age. Another fact that is indisputable, at least for the very foreseeable future, is that you will not live forever. However, there is a great likelihood that you can enjoy a quality of life of vitality well into your senior years because of research into the medical science of hormone replacement and supplementation.

Aging: Fight it or embrace it?
The average life span of an American continues to increase. The current life expectancy of 72 (male) and 79 (female) increases into the mid-eighties IF you can make it to age 65 and now, British researchers think that if you make it to 65 you can get a few more years and should make it to 90! It is also estimated by many gerontologists that by 2050, life expectancy will be well over 100 years old and that there will be millions of Americans at those ages. So if you are 50 now, in the year 2006, the odds will be pretty good that with a healthy lifestyle and regular physical examinations you will make it to vote in the 2056 Presidential Elections.

 

Is living longer any good if you are not “living?”
With any discussion about increased life expectancy comes the question posed by many: “Do I want to live longer if my mental and physical abilities are impaired?”

There are many who say that we should not seek to live longer if living longer means institutional care, living with chronic pain from disease, or living with impaired mental faculties. But is this the only lifestyle option there is with advanced age? Disability?

There are a growing number of doctors who say that old age does not inevitably bring disability. That the key to enjoying our later years, that is remaining active, mentally alert and independent may rest with hormone replacement therapy.

Can we really control the aging process?

Is it possible to roll back the hands of time and give ourselves a more youthful vigor even when we reach ages that doctors tell us we should consider vitality a thing of the past?

Hormone supplementation is a choice, one that needs to be made by a patient who understands the realistic goals of its benefits and a practitioner who understands the need of moderation—doing just enough and not more to enhance the delicate hormonal balance of our bodies.

What are hormones?
What is hormone supplementation?
How does it enhance vitality even as we age?

Hormones are chemicals within our bodies responsible for many things including the regulation of our metabolism, immune function, blood pressure, sugar levels, body temperature as well as a host of other

Hormone Supplementation Parts 1 2 3

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